Plasma proteomic profiling revealed significant differences in 180 proteins between SCAD patients and healthy controls, with PKD2, FAF2, PRDX6, MAP3K5, and IRAG2 being the most significant (p<0.001).
Case-Control (n=141)
Does the plasma proteomic profile differ between patients with spontaneous coronary artery dissection and healthy matched controls?
Exploratory proteomic profiling identified 180 proteins with significantly different abundance in SCAD patients compared to healthy controls, suggesting involvement of immune system and oxidative stress pathways.
valor p: p=<0.001
Abstract Background Spontaneous coronary artery dissection (SCAD) is a non-atherosclerotic cause of acute coronary syndrome that predominantly affects women. Genomic studies suggest associations between SCAD and connective tissue disorders such as fibromuscular dysplasia. Other reports have implicated inflammation, hormonal exposures and endothelial dysfunction as possible mechanisms underlying SCAD. The circulating protein landscape in SCAD has not been characterized specifically. Defining a SCAD-specific proteomic profile may provide novel insights into disease mechanisms, markers of susceptibility and potential therapeutic targets. Purpose To investigate how protein abundance differs between SCAD patients and healthy sex and age matched controls. Methods Patients with angiographically confirmed SCAD without atherosclerotic disease were enrolled during hospitalization for acute coronary syndrome in Sweden. Blood samples were drawn two months after the event. Healthy age and sex matched controls were recruited using the Swedish population register. Plasma proteomic profiling using the Olink Reveal panel, consisting of 1034 proteins, was conducted. T-test was used to compare cases and controls in terms of biomarker levels. Results Plasma samples from 47 SCAD patients and 94 controls were analysed. The study population consisted of 94 % women with a mean age of 53 ± 9.3 years. Participant self-reported characteristics are presented in table 1. Significant biomarker differences between the groups were found for 180 proteins (figure 1), with the five most significant proteins being PKD2, FAF2, PRDX6, MAP3K5 and IRAG2 (p 0.001). Conclusions This is one of the first exploratory proteomics studies conducted on SCAD patients. Several significant proteins have been identified with mechanistic connection to the immune system, oxidative stress and multiple intracellular processes. These pathways could be involved in pathophysiological mechanisms of SCAD. Further studies are required to both validate and translate these results into clinical practice.Volcano plot test proteomics Table proteomics
Patros et al. (Fri,) conducted a case-control in Spontaneous coronary artery dissection (n=141). Plasma proteomic profiling vs. Healthy controls was evaluated on Differences in protein abundance between SCAD patients and healthy controls (p=<0.001). Plasma proteomic profiling revealed significant differences in 180 proteins between SCAD patients and healthy controls, with PKD2, FAF2, PRDX6, MAP3K5, and IRAG2 being the most significant (p<0.001).