Response functions are key observables for probing the structure and dynamics of many-body systems. We present and demonstrate a quantum-classical computational framework for computing response functions of general many-fermion systems that also provides the full bound-state spectrum. The framework employs the Lorentz integral transform and a recently developed Hamiltonian input scheme that enables practical and scalable circuit constructions for general many-fermion Hamiltonians. Within this framework, we evaluate the Lorentz integral and propose three protocols to extract response functions and bound-state structural information. We apply the method to 19 O with realistic internucleon interactions, computing both the bound-state spectrum and the response function. This demonstration indicates opportunities for exploring the structure and dynamics of a broad class of many-body systems across diverse fields.
Du et al. (2026) studied this question.