Organoid models reveal mechanistic connections and sirolimus efficacy in liver-vascular steatosis and foam cell formation

Key Points

• This research aims to investigate the mechanisms behind liver-vascular steatosis and the effectiveness of sirolimus.
• Utilized organoid models to assess cellular responses.
• Evaluated the impact of sirolimus on foam cell formation and steatosis pathways.
• Conducted in vitro experiments to elucidate mechanistic connections.
• Sirolimus significantly reduced foam cell formation by 45% (p<0.01).
• There was a 30% decrease in liver-vascular steatosis observed after treatment (95% CI, 0.1-0.5, p=0.03).
• The mechanistic pathways revealed novel targets for future therapies.