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Combinatorial therapy with radiation and anti-PD-L1 antibodies induces tumor regression by utilizing T cells to deplete myeloid-derived suppressor cells (MDSCs) via TNF-mediated signaling. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

April 1, 2014Open Access

Kombinationstherapie aus Strahlung und anti-PD-L1-Antikörper induziert eine T-Zell-vermittelte Reduktion myeloider supressiver Zellen und Tumorrückbildung

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Abstract

T-Zellen vermittelten die antitumoralen Effekte der Kombinationstherapie durch die Reduktion myeloider supressiver Zellen (MDSCs) via Tumornekrosefaktor (TNF)-vermittelter Signalgebung. Unsere Studie liefert Einblicke in immun- und strahlungsbasierte Kombinationstherapien.

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Liufu Deng

Hua Liang

Byron Burnette

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OncoImmunology

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University of Chicago

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Kombinationstherapie aus Strahlung und anti-PD-L1-Antikörper induziert eine T-Zell-vermittelte Reduktion myeloider supressiver Zellen und Tumorrückbildung

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