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May 15, 2026Journal of Functional FoodsOpen Access

Peptide GCSTVLC derived from Sipunculus nudus alleviates diabetic nephropathy partialy through NF-κB pathway regulation

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Authors

LCLiang ChenSYShurong YanXSXiaoqin Shen

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Overview

Randomized trial shows that peptide GCSTVLC reduces inflammation in diabetic nephropathy, suggesting new dietary therapies.

Key Points

  • This study aims to evaluate the renoprotective potential of marine-derived peptides from Sipunculus nudus in diabetic nephropathy.
  • Protein hydrolysates from Sipunculus nudus were fractionated and assessed for their effects in a diabetic nephropathy mouse model.
  • The novel hexapeptide GCSTVLC was identified and tested for its ability to inhibit NF-κB pathway activation in renal tubular cells.
  • Bioassay-guided purification techniques, including LC–MS/MS, were employed to isolate bioactive peptides.
  • The peptide fraction SNH-A improved renal function in diabetic nephropathy mice, indicated by reduced serum creatinine and urinary protein levels.
  • GCSTVLC significantly suppressed the production of pro-inflammatory cytokines (TNF-α, IL-1β, MCP-1) in renal tubular cells.
  • GCSTVLC inhibited phosphorylation of IκBα and NF-κB p65, blocking NF-κB activation and reducing inflammatory responses.

Cite This Study

Chen et al. (2026) studied this question.

synapsesocial.com/papers/6a06b7a1e7dec685947aa575https://doi.org/10.1016/j.jff.2026.107332
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