Effect of ultrasonic-assisted H2O2/ascorbic acid modification on Platycodon grandiflorum polysaccharide: structural characterization and in vitro functional activities
Randomized trial demonstrates improved bioactivities in polysaccharides through ultrasound modification, indicating strong potential as dietary supplements.
Key Points
The study aims to enhance the bioavailability and functional activities of Platycodon grandiflorum polysaccharides using an ultrasound-assisted modification method.
Ultrasound-assisted extraction of polysaccharides from Platycodon grandiflorum using deep eutectic solvent (DES).
Synergistic treatment with hydrogen peroxide and ascorbic acid under ultrasound for 60, 120, and 180 minutes.
Characterization of structure and in vitro bioactivities evaluated through various spectroscopic and chromatographic techniques.
DPGS-180 showed significantly higher antioxidant, hypoglycemic, and hypolipidemic activities compared to native PGS.
Molecular weight and particle size decreased with increased ultrasound duration, while solubility and galactose content increased.
The modified fractions promoted growth of beneficial bacteria, with DPGS-180 exhibiting the strongest prebiotic effect.