Three-Component Carbopentafluorosulfanylation of Activated Alkenes with SF 5 Cl and Quinoxalin-2(1 H )-ones

For the first time, we herein report an efficient and general method to access a series of high-value compounds concurrently containing quinoxalin-2(1H)-one and SF5 moieties through a three-component reaction strategy by direct carbopentafluorosulfanylation of styrene with SF5Cl and quinoxalin-2(1H)-ones. The protocol enjoys mild reaction conditions, good functional group tolerance, and broad substrate scope, which was further evidenced by the synthesis of complex natural products and pharmaceuticals. A plausible mechanism involving SF5 radical addition to the C = C double bond, followed by capture of quinoxalin-2(1H)-one, is proposed.