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This research aims to evaluate the antifungal properties of Murrayone against Botrytis cinerea.

May 15, 2026Journal of Agricultural and Food Chemistry0 citations

Murrayone: A Promising New Fungicide Destroying the Oxidative Homeostasis and Cell Membrane Integrity of Botrytis cinerea

WZWanyun ZhuNatural Resources Conservation Service YYYao YuChinese Academy of Sciences LXLi XChinese Academy of Tropical Agricultural Sciences

Key Points

This research aims to evaluate the antifungal properties of Murrayone against Botrytis cinerea.
Assessed the effects of Murrayone on sporulation, spore germination, and disease severity in blueberries.
Conducted transcriptome analysis and evaluated reactive oxygen species accumulation and mycelial dry weight.
Performed seed germination assays to assess safety.
Murrayone significantly inhibited sporulation and spore germination compared to controls.
Recorded a notable reduction in disease severity in treated blueberry fruits.
Demonstrated cellular morphological damage and disruption of oxidative homeostasis.

Abstract

. Treatment with Murrayone caused severe cellular morphological damage, significantly inhibited sporulation and spore germination, reduced disease severity in blueberry fruits, and demonstrated its safety in seed germination assays. Transcriptome analysis revealed that its mechanism involves the disruption of oxidative homeostasis and damage to the cell membrane. The multitarget and multipathway antifungal effects of Murrayone were preliminarily verified by assessing reactive oxygen species (ROS) accumulation, propidium iodide (PI) staining, and mycelial dry weight. This study demonstrates the potential of Murrayone as an antifungal agent and elucidates its mode of action, providing a theoretical foundation for further exploration of Murrayone as a sustainable antifungal strategy.

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