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May 15, 2026Free Radical Research1 citations

Antioxidant Reactivity of Nickel and Zinc Porphyrins Revealed by Electrochemical, Spectroscopic and Molecular Modelling Approaches

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MBMohammed Larbi BenamorELElhafnaoui LanezLZLalmi Zerrouk

Key Points

  • The aim is to investigate the antioxidant reactivity of nickel and zinc porphyrins using various analytical techniques.
  • Conducted molecular dynamics simulations and MM-GBSA analyses
  • Utilized electrochemical and spectroscopic approaches to evaluate antioxidant behavior
  • Assessed binding interactions of NiTPP and ZnTMPP with Keap1
  • Findings indicate NiTPP exhibits stronger binding and greater structural stability with Keap1
  • ZnTMPP promotes direct radical scavenging as part of its antioxidant response
  • NiTPP demonstrates enhanced protein recognition compared to ZnTMPP

Abstract

). Molecular dynamics and MM-GBSA analyses confirmed greater structural stability and stronger binding for the NiTPP-Keap1 complex. These findings highlight a complementary antioxidant behavior, where ZnTMPP favors direct radical scavenging, while NiTPP shows enhanced protein recognition and stabilization.

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Cite This Study

Benamor et al. (2026) studied this question.

synapsesocial.com/papers/6a06b7eae7dec685947aa8c4https://doi.org/10.1080/10715762.2026.2672453
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