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May 15, 2026Journal of Microbiology and Biotechnology

Prediction-Guided Biotransformation of p -Hydroxyphenethyl Anisate into a Novel 3',4'-Dihydroxyphenethyl Anisate with Potent Anti-Inflammatory, Anti-Melanoma, and Antioxidant Activities

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Authors

CWChien-Yu WuHDHsiou‐Yu DingHTHuei‐Ju Ting

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Overview

Randomized trial demonstrates enhanced anti-inflammatory activity in macrophages, indicating novel therapeutic potential.

Key Points

  • To investigate the biotransformation of p-hydroxyphenethyl anisate into 3',4'-dihydroxyphenethyl anisate and its therapeutic effects.
  • Biotransformation of p-hydroxyphenethyl anisate to 3',4'-dihydroxyphenethyl anisate.
  • Assessment of anti-inflammatory activity in lipopolysaccharide-stimulated RAW 264.7 macrophages.
  • Western blot analysis to evaluate iNOS expression.
  • 3',4'-dihydroxyphenethyl anisate showed an 11-fold increase in anti-inflammatory activity compared to p-hydroxyphenethyl anisate.
  • Significant downregulation of iNOS expression was confirmed at the protein level.
  • The novel compound demonstrated preliminary antioxidant capacity and observable anti-melanoma activity.

Cite This Study

Wu et al. (2026) studied this question.

synapsesocial.com/papers/6a06b81ce7dec685947aaaa3https://doi.org/10.4014/jmb.2601.01040
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