Right atrial global longitudinal strain measured by 2D-STE was significantly lower in fetuses with tricuspid regurgitation and left ventricular outflow tract obstruction than in controls (p<0.01).
Observational (n=157)
Does right atrial global longitudinal strain (RAGLS) assessed by 2D-STE differ between normal fetuses and those with LVOTO or moderate-to-severe TR?
2D-STE-derived RAGLS is a feasible and sensitive indicator for quantitatively evaluating right atrial dysfunction in fetuses with cardiac anomalies like LVOTO and TR.
p-value: p=<0.01
PURPOSE: To evaluate the feasibility of two-dimensional speckle tracking echocardiography (2D-STE) for quantitatively assessing right atrial global longitudinal strain (RAGLS) in normal fetuses, and to compare RAGLS among normal fetuses, fetuses with left ventricular outflow tract obstruction (LVOTO), and those with moderate-to-severe tricuspid regurgitation (TR). METHODS: A total of 32 fetuses with LVOTO, 25 with moderate-to-severe TR, and 100 normal fetuses were enrolled. RAGLS was compared among the three groups, and its correlations with gestational age (GA) and other echocardiographic parameters were analyzed. Inter- and intra-observer repeatability was assessed using intraclass correlation coefficients (ICC) and Bland-Altman analysis. RESULTS: RAGLS differed significantly among the three groups (p 0.05). The inter- and intra-observer repeatability of RAGLS measurements was good (ICC > 0.75). CONCLUSION: The right atrial reservoir function is impaired in fetuses with TR and those with LVOTO. RAGLS may serve as a sensitive indicator for quantitatively evaluating RA dysfunction in fetal cardiac anomalies.
Yang et al. (2026) conducted an observational in Fetal left ventricular outflow tract obstruction and tricuspid regurgitation (n=157). Two-dimensional speckle tracking echocardiography (2D-STE) for RAGLS vs. Normal fetuses was evaluated on Right atrial global longitudinal strain (RAGLS) (p=<0.01). Right atrial global longitudinal strain measured by 2D-STE was significantly lower in fetuses with tricuspid regurgitation and left ventricular outflow tract obstruction than in controls (p<0.01).