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May 15, 2026ChemCatChem

Mitigation of Light‐Triggered Amine Transaminase Inactivation Through Immobilization on Boronic‐Functionalized Supports

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Authors

MIMaialen IturraldeEDEleftheria DiamantiFLFernando Lopez-Gallego

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Overview

Randomized trial explores enzyme stabilization in transaminases using boronic functionalized supports, indicating improved operational half-life.

Key Points

  • The research aims to prevent light-induced inactivation of PLP-dependent amine transaminases by employing enzyme immobilization techniques.
  • Developed a strategy utilizing boronic-functionalized supports for enzyme stabilization
  • Evaluated the effects of HEPES buffer and light exposure on the stability of Pf ATA
  • Created a self-sufficient heterogeneous biocatalyst by co-immobilizing multiple enzymes and cofactors.
  • Extended half-life of Pf ATA by a factor of four compared to its free form
  • Achieved quantitative aldehyde amination in the first reaction cycle under ambient light
  • Recycling of enzymes and cofactors was limited, suggesting a need for system optimization.

Cite This Study

Iturralde et al. (2026) studied this question.

synapsesocial.com/papers/6a06b888e7dec685947aaf91https://doi.org/10.1002/cctc.70782
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