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May 15, 2026Molecular MedicineOpen Access

TRMT6/61A-mediated tRNA m1A methylation promotes codon-dependent TAB2 translation and drives AML progression

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Authors

ZJZhirong JiaXWXiang WuAOAorong Ouyang

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Overview

Randomized trial reveals the role of TRMT6/TRMT61A in promoting leukemogenesis in AML, suggesting potential targeted therapy strategies.

Key Points

  • This research aims to elucidate the role of TRMT6/TRMT61A in tRNA m1A methylation and its impact on AML progression.
  • Functional assays conducted in vitro and in vivo to assess the role of TRMT6/TRMT61A in AML.
  • Evaluation of TRMT6/TRMT61A expression levels in AML and their correlation with patient prognosis.
  • Use of knockdown techniques to analyze effects on proliferation and apoptosis in AML cells.
  • TRMT6/TRMT61A was significantly upregulated in AML, correlating with poor prognosis.
  • TRMT6/61A knockdown in AML cells inhibited proliferation and induced apoptosis.
  • In mouse xenograft models, TRMT6/61A knockdown reduced tumor burden and improved survival.

Cite This Study

Jia et al. (2026) studied this question.

synapsesocial.com/papers/6a06b888e7dec685947ab042https://doi.org/10.1186/s10020-026-01496-3
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