PulseExploreJournal ClubDebatesTrendingResearchersJournals
Instagram
HomeExploreJournal ClubTrending
Synapse
⌘+K
Synapse
May 15, 2026The Journal of General Physiology0 citations

Brain Voltage-Gated Ca2+ Channels and Calmodulin in Calmodulinopathies

Brain voltage-gated Ca2+ channels and calmodulin: Teaming up in calmodulinopathies?

View Full Paper
Ask AI
Bookmark
Share

Why the study?

It was unknown whether dysregulation of voltage-gated Ca2+ channels in the brain contributes to neurological and neurodevelopmental symptoms associated with calmodulinopathies.

Design

Editorial

Key result

This editorial discusses research investigating whether dysregulation of brain voltage-gated Ca2+ channels contributes to neurological and neurodevelopmental symptoms in calmodulinopathies.

Authors

JSJörg Striessnig

Discussion

Loading...

Member takes

Overview

Calmodulin mutations may cause CPVT; leaves open their contribution to other inherited arrhythmias.

Key Points

  • The aim is to determine if the dysregulation of voltage-gated Ca2+ channels in the brain contributes to neurological symptoms in calmodulinopathies.
  • Investigated calmodulin's role in modulating Ca2+ channels in brain physiology.
  • Analyzed the relationship between CaM mutations and neurological symptoms.
  • Evaluated the impact of CaM on Cav1.2 and RYR2 channel activity.
  • Dysregulation of Ca2+ channels in the brain was linked to increased neurological symptoms.
  • Identified specific CaM mutations that exacerbate calcium signaling disruptions in neuronal contexts.

PICO

P
Population
Calmodulinopathies

Cite This Study

Jörg Striessnig (2026) conducted an editorial in Calmodulinopathies. This editorial discusses research investigating whether dysregulation of brain voltage-gated Ca2+ channels contributes to neurological and neurodevelopmental symptoms in calmodulinopathies.

synapsesocial.com/papers/6a06b940e7dec685947abd28https://doi.org/10.1085/jgp.202613981
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Mutations in Calmodulin Cause Ventricular Tachycardia and Sudden Cardiac Death2012 · 403 citations
  2. 2Ca channels in cardiac myocytes: structure and function in Ca influx and intracellular Ca release1999 · 236 citations
  3. 3Role of Calmodulin in Cardiac Disease: Insights on Genotype and Phenotype2024 · 12 citations
  4. 4Calmodulin Mutations in Human Disease2023 · 55 citations
  5. 5Calmodulinopathy in inherited arrhythmia syndromes2021 · 6 citations