The aim is to evaluate the therapeutic potential of targeted degradation of PHD1 in acetaminophen-induced acute liver injury.
Identifying SH-26 as a PHD1 degrader
Demonstrating the utility of SH-26 as a chemical tool
Investigating the pathological role of PHD1 in acute liver injury
SH-26 effectively degrades PHD1
PHD1 degradation offers protection against acetaminophen-induced liver injury
Novel therapeutic strategy identified for acute liver injury management
Abstract
protection against ALI. Collectively, our work identifies SH-26 as the first effective PHD1 degrader and demonstrates its utility as a chemical tool to dissect the pathological role of PHD1 in ALI.