A BSTRACT Background: Primary hyperparathyroidism (PHPT) is characterized by the hypersecretion of parathyroid hormone, leading to hypercalcemia and various clinical manifestations. Objective: This study aimed to assess the clinical profile and postoperative course of patients presenting with Primary hyperparathyroidism. Additionally, to correlate serum calcium and phosphorus levels with outcomes following parathyroidectomy. Materials and Methods: Forty-five patients diagnosed with primary hyperparathyroidism were included in this retrospective study, with data collected from hospital records. The diagnosis of primary hyperparathyroidism was confirmed based on inappropriately elevated parathyroid hormone levels despite elevated or normal albumin-adjusted calcium levels and imaging findings. We assessed clinical presentations, laboratory investigations and radiological features. Results: The mean age of presentation in our study was 49.37 ± 17.38 years. The most prevalent clinical manifestation was kidney-related such as renal stones, affecting 40% of cases, followed by musculoskeletal symptoms which were 26.66% and gastrointestinal manifestations were 15.55% of the patients while 17.77% of the patients were asymptomatic. A positive correlation was identified between preoperative parathyroid hormone and calcium levels. Post-surgery, there were significant reductions in the mean calcium and parathyroid hormone levels, with decreases of 3.21 mg/dL and 629.54 pg/mL, respectively ( P value < 0.001 for both). Conclusion: Primary hyperparathyroidism presents at a young age in our country, with the majority of patients being symptomatic. The most common presentation was with renal stones. They exhibit diverse biochemical profiles, and successful outcomes are achieved following parathyroidectomy.
Srinivasreddy et al. (2026) studied this question.