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May 15, 2026Journal of Istanbul Faculty of Medicine / İstanbul Tıp Fakültesi DergisiOpen Access

Combined Effects of Retinoic Acid and Selenium on Cell Viability in Sh-Sy5y Neuroblastoma Cells

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Authors

ABAyhan BılırBYBerna YıldırımBBBurcu Biltekin

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Overview

Randomized trial demonstrates combined cytotoxic effects of retinoic acid and selenium in neuroblastoma cells, highlighting therapeutic potential.

Key Points

  • This research aims to explore how retinoic acid and selenium affect cell viability in SH-SY5Y neuroblastoma cells, individually and together.
  • SH-SY5Y cells treated with retinoic acid and selenium at 1, 10, or 100 μM concentrations, alone or in combination.
  • Cell viability assessed using the trypan blue exclusion assay at 48 and 72 hours.
  • Statistical analyses conducted using one-way or two-way ANOVA with Dunnett’s post hoc test.
  • Retinoic acid caused a significant reduction in cell viability, particularly at 100 μM, leading to near-complete loss of viable cells.
  • Selenium decreased cell viability as well, with significant effects only at higher concentrations.
  • The combination of retinoic acid and selenium exhibited a synergistic cytotoxic effect, stronger than either treatment alone.

Cite This Study

Bılır et al. (2026) studied this question.

synapsesocial.com/papers/6a06b983e7dec685947ac46ahttps://doi.org/10.26650/iuitfd.1827318
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