A high lactate-to-albumin ratio was independently associated with increased 28-day mortality in patients with sepsis-induced cardiomyopathy (adjusted OR 1.42; 95% CI 1.04-1.93).
Cohort (n=1,810)
No
Does a high lactate-to-albumin ratio predict 28-day mortality in patients with sepsis-induced cardiomyopathy?
The lactate-to-albumin ratio is an independent predictor of 28-day mortality in patients with sepsis-induced cardiomyopathy, suggesting its utility as a practical biomarker for risk stratification.
Effect estimate: adjusted OR 1.42 (95% CI 1.04-1.93)
p-value: p=<0.001
The lactate-to-albumin ratio (LAR) has been reported as a prognostic marker in various diseases, but its association with outcomes in patients with sepsis-induced cardiomyopathy (SICM) remains unclear. This study aimed to evaluate the prognostic value of LAR in SICM patients. We retrospectively analyzed data from SICM patients admitted to the intensive care unit (ICU) of Beth Israel Deaconess Medical Center between 2008 and 2022. LAR was calculated using laboratory values obtained within 24 h of ICU admission. The optimal LAR cutoff was determined using R software. Survival analysis was performed with Kaplan–Meier curves, and multivariate logistic regression models were used to assess the association between LAR and 28-day mortality. Restricted cubic spline (RCS) analysis explored the dose–response relationship, and subgroup analyses evaluated consistency across populations. Among 1,810 included patients, the optimal LAR cutoff was 1.094. Kaplan–Meier analysis showed significantly higher 28-day mortality in the high-LAR group (log-rank P < 0.001). Multivariate logistic regression confirmed LAR as an independent predictor of mortality (adjusted OR = 1.42, 95% CI: 1.04–1.93). RCS revealed a non-linear relationship between LAR and mortality ( P for non-linear = 0.001), and subgroup analyses showed no significant interactions. LAR is independently associated with short-term prognosis in SICM patients and may serve as a practical biomarker for risk stratification.
Jian Deng (2026) conducted a cohort in Sepsis-induced cardiomyopathy (SICM) (n=1,810). Lactate-to-albumin ratio (LAR) vs. Low lactate-to-albumin ratio was evaluated on 28-day mortality (adjusted OR 1.42, 95% CI 1.04-1.93, p=<0.001). A high lactate-to-albumin ratio was independently associated with increased 28-day mortality in patients with sepsis-induced cardiomyopathy (adjusted OR 1.42; 95% CI 1.04-1.93).