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April 14, 2026International Journal of Biological Macromolecules0 citationsOpen Access

Deciphering high density lipoprotein (HDL) structure-function: Detailed analysis of HDL subfractions reveals molecular differences leading to atherosclerosis risk

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YCYubexi CorreaBFBirgit FeldererMJMartin Jansen

Key Result

Multimodal analysis integrating structural and biochemical data of HDL subfractions separated risk groups and revealed correlations between structural parameters and cardiovascular risk status.

Study Design

Type

Observational

Structured PICO

I
Intervention
Multimodal analysis integrating structural and biochemical data of HDL subfractions
O
Outcome
Separation of risk groups and correlations between structural parameters and cardiovascular risk statussurrogate

Analyzing HDL subfractions using multimodal structural and biochemical data may uncover novel biomarkers for atherosclerosis risk.

Limitations

  • Requires validation in larger cohorts

Abstract

addressing that particle composition alone cannot fully distinguish HDL dysfunction. Multimodal analysis integrating structural and biochemical data was able to separate risk groups and revealed correlations between structural parameters and cardiovascular risk status. Our findings support the importance of analyzing HDL subfractions to uncover molecular drivers of disease risk and suggest candidate biomarkers for atherosclerosis upon validation in larger cohorts.

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Cite This Study

Correa et al. (2026) conducted an observational in Atherosclerosis risk. Multimodal analysis of HDL subfractions was evaluated on Correlations between structural parameters and cardiovascular risk status. Multimodal analysis integrating structural and biochemical data of HDL subfractions separated risk groups and revealed correlations between structural parameters and cardiovascular risk status.

synapsesocial.com/papers/6a07b64f7ba19a189e06b4d9https://doi.org/10.1016/j.ijbiomac.2026.152016
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