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May 16, 2026Acta Physiologica1 citationsOpen Access

Mechanisms of Uncoupling Protein 1 in Brown Fat Thermogenesis

A Structural Context for the Mechanisms of Uncoupling Protein 1 in Brown Fat Thermogenesis

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Authors

RCRiccardo CavalieriMRMargeoux A. S. Dela RosaCCCamila A. Cotrim

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Overview

Review outlines mechanisms of uncoupling protein 1 related to thermogenesis in brown fat, suggesting implications for metabolic health.

Key Points

  • This review aims to elucidate the structural and functional mechanisms of uncoupling protein 1 (UCP1) in brown fat thermogenesis.
  • Reviewed recent cryo-EM structures of UCP1 to understand nucleotide inhibition and transport mechanisms.
  • Evaluated past structure-function relationships in the context of new molecular insights.
  • Highlighted hypotheses regarding purine nucleotide binding discrimination and key protein features.
  • Clarified how UCP1 operates through proton leak independent of ATP production.
  • Identified novel bonding features that support protein state changes and thermogenic activity.
  • Proposed new hypotheses to explain the discrimination in binding of purine nucleotides.
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Cite This Study

Cavalieri et al. (2026) studied this question.

synapsesocial.com/papers/6a0808afa487c87a6a40ae3ahttps://doi.org/10.1111/apha.70246
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Uncoupling Protein 1 Does Not Produce Heat without Activation2022 · 32 citations
  2. 2UCP1-Dependent Thermogenic Adipose Tissue in Human Disease: Adipose-Centered Mechanisms, Biomarker Limitations, and Translational Perspectives2026
  3. 3Comparative functional analysis reveals differential nucleotide sensitivity between human and mouse <scp>UCP1</scp>2024 · 1 citations
  4. 4UCP2, a Member of the Mitochondrial Uncoupling Proteins: An Overview from Physiological to Pathological Roles2024 · 24 citations
  5. 5Deciphering Uncoupling Proteins in Cellular Homeostasis and Metabolic Health2026