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May 16, 2026Journal of the American Chemical Society3 citations

Sinefungin Biosynthesis Employs a B 12 -Dependent Radical S -Adenosyl- l -methionine Enzyme Catalyzing C-Adenosylation of Arginine

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KUKoki UenoRURichiro UshimaruYYYi Yang

Key Points

  • The aim is to explore the biosynthesis of sinefungin and identify the enzymatic processes involved.
  • Investigation of the radical SAM enzyme family
  • Characterization of the enzyme's activity
  • Analysis of the assembly pathway for conjugates
  • Identification of a novel B12-dependent radical SAM enzyme
  • Revealed unique mechanisms for C-adenosylation of arginine
  • Demonstrated unconventional pathways for amino acid-nucleoside conjugate synthesis

Abstract

-dependent radical SAM enzyme family and unveils an unconventional assembly pathway for amino acid-nucleoside conjugates in nature.

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Cite This Study

Ueno et al. (2026) studied this question.

synapsesocial.com/papers/6a0808ffa487c87a6a40b173https://doi.org/10.1021/jacs.6c05246
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