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May 16, 2026Journal of Agricultural and Food Chemistry0 citations

Ameliorating High-Fat Diet-Induced Obesity and Metabolic Disorders in Mice by Simultaneous Oral Administration of a Xylanase and Wheat Bran

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ZHZhenzhen HaoJGJianzhong GeYSYanpeng Sun

Key Points

  • The aim is to investigate the effects of xylanase and wheat bran on obesity and metabolic disorders in mice.
  • Mice were administered xylanase and wheat bran concurrently.
  • Changes in lipid metabolism and gut microbiota were analyzed.
  • Spearman analysis assessed associations between gut microbes, metabolites, and obesity indicators.
  • Co-administration significantly improved steroid hormone biosynthesis and sphingolipid levels.
  • A strong association was found between gut microbes and obesity-related indicators.
  • The strategy effectively alleviated high-fat diet-induced obesity in mice.

Abstract

Xyn10C with wheat bran greatly affected lipid metabolism, particularly steroid hormone biosynthesis and sphingolipids. Spearman analysis revealed close association between the gut microbes, their metabolites, and obesity-related indicators. In conclusion, oral co-administration of a xylanase with wheat bran represents a valuable strategy for alleviating HFD-induced obesity.

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Cite This Study

Hao et al. (2026) studied this question.

synapsesocial.com/papers/6a0808ffa487c87a6a40b1e8https://doi.org/10.1021/acs.jafc.5c17603
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