Autoimmune Hepatitis Following COVID ‐19 Vaccination in a Patient With Ulcerative Colitis: A Case Report

ABSTRACT Autoimmune hepatitis (AIH) following COVID‐19 vaccination is a rare adverse event. We present the case of a 55‐year‐old male with a history of ulcerative colitis (UC) who developed AIH 3 weeks after receiving his second dose of the Pfizer–BioNTech mRNA vaccine. He presented with jaundice and significantly elevated liver enzymes. A liver biopsy confirmed the diagnosis of AIH. The patient was successfully treated with corticosteroids and azathioprine, leading to complete clinical and biochemical remission. This case highlights the potential for vaccine‐induced autoimmune phenomena, particularly in individuals with preexisting autoimmune conditions, and underscores the importance of prompt diagnosis and treatment.