Randomized trial evaluates the impact of 50 Hz magnetic fields on the hematopoietic system in humanized mice, suggesting safety for normal human hematopoiesis.
Key Points
This study aims to assess the effects of 50 Hz magnetic field exposure on the human hematopoietic system using humanized mice.
Developed a 50 Hz magnetic field exposure system for uniform exposure of humanized mice.
Humanized mice were exposed to a 5 mT(rms) MF for 2 months after transplanting human hematopoietic stem and progenitor cells.
Monitored chimerism rates of human leukocytes in hematopoietic organs post-exposure.
Chimerism rates of human leukocytes in hematopoietic organs of the MF-exposed group were comparable to the control group.
Exposure to the 50 Hz MF did not affect early differentiation of human B cells in the bone marrow.
The findings support previous in vitro results, validating the utility of humanized mice for further MF evaluations.