Cardiovascular MRI effectively differentiated Anderson-Fabry disease from HCM, with AFD showing lower septal native T1 values (P<0.001) and more frequent basal inferolateral LGE (P<0.001).
Case-Control (n=90)
Does cardiovascular magnetic resonance imaging (CMR) at 3.0 T differentiate Anderson-Fabry disease with the c.640-801G > A mutation from hypertrophic cardiomyopathy?
CMR effectively differentiates late-onset Anderson-Fabry disease from hypertrophic cardiomyopathy using lower native T1 values, basal inferolateral LGE, and symmetric LVH.
p-value: p=<0.001
Aims: To evaluate the utility of cardiovascular magnetic resonance imaging (CMR) in distinguishing Anderson-Fabry disease (AFD) harboring the c.640-801G > A mutation from hypertrophic cardiomyopathy (HCM). Methods and results: We enrolled 30 AFD patients, 30 age- and sex-matched HCM patients, and 30 healthy controls (HC). All participants underwent CMR (3.0 T). Left ventricular hypertrophy (LVH) prevalence was high in both AFD and HCM groups (P = 0.12). AFD patients exhibited significantly greater left ventricular lateral wall thickness compared to both HCM and HC (P A mutation from HCM. Key discriminators include lower native T1 values (Caution against pseudo-normalization), higher prevalence of basal inferolateral LGE, and more symmetric LVH in AFD.
Xu et al. (2026) conducted a case-control in Anderson-Fabry disease and hypertrophic cardiomyopathy (n=90). Cardiovascular magnetic resonance imaging (CMR) vs. Hypertrophic cardiomyopathy and healthy controls was evaluated on Septal native T1 values (p=<0.001). Cardiovascular MRI effectively differentiated Anderson-Fabry disease from HCM, with AFD showing lower septal native T1 values (P<0.001) and more frequent basal inferolateral LGE (P<0.001).