PulseExploreJournal ClubResearchersJournals
Instagram
HomeJournal ClubExplore
Synapse
⌘+K
Synapse
May 24, 2013Circulation Heart FailureOpen Access

Treatment of Obstructive Hypertrophic Cardiomyopathy Symptoms and Gradient Resistant to First-Line Therapy With β-Blockade or Verapamil

View Full Paper
Ask AI
Bookmark
Share

Why the study?

Does stepped management with disopyramide and/or septal reduction therapy improve symptoms, gradients, and survival in patients with obstructive hypertrophic cardiomyopathy resistant to beta-blockers or verapamil?

Population

299 patients with obstructive hypertrophic cardiomyopathy and limiting symptoms resistant to first-line…

Comparison

Stepped management including addition of… vs Nonobstructed hypertrophic cardiomyopathy…

Design

Cohort

Follow-up

4.8 years

Authors

MSMark V. SherridASAneesha ShettyGWGlenda Winson

Discussion

Loading...

Member takes

Overview

Supports stepped therapy in refractory obstructive HCM; hypothesis-generating without randomized confirmation.

Structured PICO

Does stepped management with disopyramide and/or septal reduction therapy improve symptoms, gradients, and survival in patients with obstructive hypertrophic cardiomyopathy resistant to beta-blockers or verapamil?

P
Population
299 patients with obstructive hypertrophic cardiomyopathy and limiting symptoms resistant to first-line therapy with beta-blockade or verapamil
I
Intervention
Stepped management including addition of disopyramide (74%) and/or surgical myectomy (46%) or alcohol septal ablation (2%)
C
Comparator
Nonobstructed hypertrophic cardiomyopathy patients and a matched cohort of the US population (for survival analysis)
O
Outcome
Resting gradient, New York Heart Association (NYHA) class, and 10-year Kaplan-Meier survivalhard clinical

Stepped management with disopyramide and surgical myectomy provides excellent long-term survival and symptom relief in patients with obstructive HCM refractory to first-line medical therapy.

Cite This Study

Sherrid et al. (2013) studied this question.

synapsesocial.com/papers/6a08db0b02034f20cae4ab84https://doi.org/10.1161/circheartfailure.112.000122
View Full Paper
Ask AI
Bookmark
Share