Intermittent Cobalt (II, III) Oxide Exposure Exacerbates Inflammatory Injury through Tumor Necrosis Factor-Alpha-Dependent Bone Marrow-Mediated Trained Immunity

Puntos clave

• This research investigates how intermittent exposure to cobalt oxide affects inflammatory injury through trained immunity and TNF-alpha.
• Examined the effects of intermittent cobalt oxide exposure on inflammatory responses in distant organs.
• Analyzed the role of TNF-alpha in mediating trained immunity related to cobalt oxide exposure.
• Intermittent cobalt oxide exposure significantly increased inflammatory injury in the heart and brain.
• Trained immunity was identified as a key mechanism linking cobalt oxide nanoparticles to increased inflammation.
• Elevated levels of TNF-alpha were found to correspond with heightened inflammatory responses.