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May 17, 2026PLoS ONE0 citationsOpen Access

Expression of Concern: Signaling Networks Associated with AKT Activation in Non-Small Cell Lung Cancer (NSCLC): New Insights on the Role of Phosphatydil-Inositol-3 kinase

TEThe PLOS One Editors

Key Points

  • The aim is to address concerns regarding the integrity of the published findings on AKT activation signaling in NSCLC.
  • Identification of issues in peer review
  • Concerns raised regarding the quality of figures and panels included in the article.
  • Numerous vertical discontinuities were noted in the figures, specifically in PI3KCA and Tubulin panels of Fig 6B.
  • Vertical discontinuities were also present in AKT1 and Actin panels of Fig S1A.

Abstract

After this article 1 was published, the PLOS One Editors identified concerns about the article's peer review and with Figs 1-6 and S1-S5.Specifically: There appear to be vertical discontinuities between lanes 2 and 3 in the PI3KCAand Tubulin panels of Fig 6B. There appear to be vertical discontinuities between lanes 2 and 3 in the left AKT1 and left Actin panels of Fig S1A.

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Cite This Study

The PLOS One Editors (2026) studied this question.

synapsesocial.com/papers/6a095a877880e6d24efe0718https://doi.org/10.1371/journal.pone.0349359
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Correction: Expression of Concern: Signaling Networks Associated with AKT Activation in Non-Small Cell Lung Cancer (NSCLC): New Insights on the Role of Phosphatydil-Inositol-3 kinase2026
  2. 2[Expression of Concern] ETS‑1: A potential target of glycolysis for metabolic therapy by regulating glucose metabolism in pancreatic cancer2025
  3. 3Abstract ED10-02: Identifying Collateral Vulnerabilities in the AKT pathway for Therapeutic Benefit2024
  4. 4A single center experience on <scp>PI3K</scp>/<scp>AKT</scp>/<scp>MTOR</scp> signaling defects: Towards pathogenicity assessment for four novel defects2024 · 1 citations
  5. 5[Expression of Concern] MicroRNA‑195 targets VEGFR2 and has a tumor suppressive role in ACHN cells via PI3K/Akt and Raf/MEK/ERK signaling pathways2025