Discovery of Novel Alkynylbenzene Scaffold-Based PTPN2-Selective Degrader PD-305 with Exceptional Potency and In Vivo Efficacy

Key Points

• This research aims to identify a selective degrader for PTPN2 with high potency and efficacy.
• Development of novel alkynylbenzene scaffold.
• Evaluation of PD-305's potency and effectiveness in vivo.
• PD-305 exhibits exceptional potency against PTPN2.
• Demonstrated significant in vivo efficacy, warranting further research.