Combined PD-1 and TIGIT blockade via siRNA enhances anti-leukemic T-cell function and promotes AML cell apoptosis

Puntos clave

• This research aims to evaluate the effects of combined PD-1 and TIGIT blockade on T-cell function and apoptosis in acute myeloid leukemia (AML).
• Utilized siRNA for combined blockade of PD-1 and TIGIT
• Assessed anti-leukemic T-cell functionality
• Investigated effects on AML cell apoptosis
• Increased T-cell effector function observed following PD-1 and TIGIT blockade
• Enhanced apoptosis rates in AML cells when treated with combined approach
• Supports potential for improved strategies in AML immunotherapy