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May 17, 2026ACS Catalysis

Enantioselective Cu/Pd Cocatalyzed Allylboration of 1,3-Dienes

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Authors

LJLiyin JiangKZKangbao ZhongWSWenze Shi

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Overview

Randomized trial demonstrates enantioenriched product synthesis in 1,3-dienes, suggesting efficient catalysis.

Key Points

  • This work aims to develop a methodology for converting 1,3-dienes into enantioenriched complex molecules.
  • Utilized a chiral sulfoxide-phosphine ligand in Cu/Pd cooperative catalysis.
  • Conducted mechanistic studies including experimental approaches and DFT calculations.
  • Demonstrated borylation of 1,3-diene using B2(pin)2 and allyl carbonate.
  • Achieved 80% yield of borylated 1,5-dienes with a diastereomeric ratio (d.r.) of 18:1.
  • Obtained enantiomeric excess (ee) up to 98%, indicating high enantioselectivity.
  • Showed potential for downstream product diversification with synthesized borylated products.

Cite This Study

Jiang et al. (2026) studied this question.

synapsesocial.com/papers/6a095a877880e6d24efe0757https://doi.org/10.1021/acscatal.6c01705
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