Facilitators, barriers and intervention strategies for medication adherence in patients receiving thyroid hormone replacement therapy: a mixed-methods systematic review

STATEMENTS OF CONTRIBUTION: We employed a mixed-methods approach, integrating perspectives from key stakeholders (e.g., patients, healthcare providers) to explore factors influencing medication adherence in patients undergoing THRT.The top three significant barriers were inconvenient administration times, lack of disease knowledge and lack of medication knowledge. The top three facilitators were older age, regular follow-up and positive anticipated outcomes.The study highlights the interplay of individual, interpersonal, healthcare and socioeconomic factors, emphasizing that barriers and facilitators are context dependent and often interrelated. Implementing effective adherence strategies requires collaborative efforts across stakeholders to address these multifaceted challenges.