It remains unclear whether frailty and white matter lesions are risk factors for surgical treatment of unruptured intracranial aneurysms in older adults. We conducted a prospective multicenter study of 397 patients aged ≥60 years with unruptured intracranial aneurysms enrolled from 20 hospitals in Japan. Unruptured intracranial aneurysms were treated by either microsurgical clipping or endovascular treatment according to institutional protocols. The primary endpoint was functional outcome at discharge assessed using the modified Rankin scale (mRS). Poor outcome was defined as a deterioration of 1 or more points in the mRS score at discharge compared with the preoperative baseline. Unruptured intracranial aneurysm size ranged from 2.1 to 26 mm (mean, 6.93 mm). Poor outcome occurred in 52 patients (13.1%). There was no significant association between poor outcome and age (p = 0.089) or treatment modality (clipping vs. coiling, p = 0.4739). In multivariate regression analysis, poor outcome was significantly associated with larger unruptured intracranial aneurysm size (p = 0.033), higher Clinical Frailty Scale score (p = 0.006), higher preoperative mRS score (p = 0.039), lower hemoglobin level (p = 0.016), absence of regular exercise (p = 0.046), slower walking speed (p = 0.002), severe white matter lesions (p = 0.001), and lower intraoperative blood pressure (p = 0.032). Severe white matter lesions were associated with a higher risk of postoperative ischemia (p ≤ 0.042) and intracranial hemorrhage (p = 0.0017). These findings indicate that preoperative frailty and severe white matter lesions are significant predictors of poor outcomes after unruptured intracranial aneurysm surgery in older adults.
Matano et al. (2026) studied this question.