Comprehensive analysis shows distinct roles of two SWI/SNF complexes in regulating gene expression in Toxoplasma gondii, suggesting specialized control mechanisms.
Key Points
This study aims to elucidate the roles of two distinct SWI/SNF complexes in regulating transcription in Toxoplasma gondii.
Integrated transcriptomics with chromatin-profiling strategies to analyze Myb protein family.
Defined composition of two SWI3 complexes: TgSNF2a and TgSNF2b.
Conducted cell cycle–resolved chromatin profiling to observe shifts in ATPase occupancy.
TgSNF2a is essential for timely transcription of regulated genes.
TgSNF2b ensures global transcriptional competency across the cell cycle.
Observations show occupancy shift from TgSNF2b to TgSNF2a as genes transition to active transcription.