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May 17, 2026Genes Chromosomes and Cancer

A Novel MEIS1::NCOA2 Fusion Gene in Acute Myeloid Leukemia

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Authors

LWLei WangXZXincun ZhongFGFeng Gao

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Overview

Case report reveals a novel fusion gene associated with acute myeloid leukemia, suggesting new research directions.

Key Points

  • To identify and characterize the MEIS1::NCOA2 fusion gene in a case of acute myeloid leukemia.
  • Targeted RNA sequencing was conducted to identify the fusion gene.
  • Sanger sequencing was used for validation of the identified fusion.
  • Analysis focused on the translocation t(2;8)(p14;q13.3) and its implications in leukemogenesis.
  • The novel fusion gene MEIS1::NCOA2 was identified in a 42-year-old woman with AML.
  • The MEIS1 breakpoint differs from classic sarcoma-associated breakpoints, preserving functional domains.
  • This case highlights the need for further investigation into the functional roles of this fusion in leukemia.

Cite This Study

Wang et al. (2026) studied this question.

synapsesocial.com/papers/6a095b3f7880e6d24efe1031https://doi.org/10.1002/gcc.70121
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Defining Roles for HOX and MEIS1 Genes in Induction of Acute Myeloid Leukemia2001 · 289 citations
  2. 2A locally aggressive pelvic MEIS1::NCOA1 fusion sarcoma in a young adult female: a case report and review of the literature2025 · 3 citations
  3. 3Hoxa9 and Meis1 Cooperatively Induce Addiction to Syk Signaling by Suppressing miR-146a in Acute Myeloid Leukemia2017 · 120 citations
  4. 4Pbx3 and Meis1 cooperate through multiple mechanisms to support Hox-induced murine leukemia2015 · 102 citations
  5. 5MEIS1::NCOA1 Primitive Spindle Cell Sarcoma of the Kidney2025 · 8 citations