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May 17, 2026The Journal of Organic Chemistry1 citations

Synthesis of Carbamoylated Phenylalanine Derivatives and Peptide Modification via Palladium-Catalyzed Ex Situ CO Insertion

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ASAnku SharmaKRKamya RaoGRGajanan K. Rathod

Key Points

  • This research aims to develop a palladium-catalyzed method for synthesizing carbamoylated phenylalanine derivatives and modifying peptides.
  • Utilized a two-chamber COware system for carbonylative coupling.
  • Targeted side chain modifications on iodo-containing peptides.
  • Synthesized peptide libraries with diverse carbamoyl motifs.
  • Successfully synthesized various carbamoyl phenylalanine derivatives.
  • Efficient conversion of iodo-group peptides provided diverse bioactive scaffolds.
  • The method enables rapid generation of modified peptide libraries.

Abstract

A versatile palladium-catalyzed carbonylative coupling protocol for the synthesis of carbamoyl phenylalanine derivatives has been described. Using a two-chamber COware system, this strategy also enables the efficient conversion of iodo-group-containing peptides into diverse carbamoyl motifs within a fully assembled peptide sequence, including bioactive scaffolds. This work provides a versatile tool for rapidly generating modified peptide libraries via targeted side chain tailoring of the phenylalanine residue.

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Cite This Study

Sharma et al. (2026) studied this question.

synapsesocial.com/papers/6a095b3f7880e6d24efe106bhttps://doi.org/10.1021/acs.joc.6c00691
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