Background:: Vulvar fibroepithelial polyps are common benign vulvar lesions, mainly originating from the submucosal layer. Usually, they are small and asymptomatic; however, they can rarely reach sizes exceeding 5 cm, at which point they are classified as “giant”. Differential diagnosis includes angiomyxoma, angiomyofibroblastoma, sarcoma, and squamous cell carcinoma. Case Presentation:: In May 2024, a 30-year-old multiparous woman (G4P4) presented with a complaint of vulvar burning. She reported a vulvar mass present since her last childbirth. At clinical examination, a 7.5 cm pedunculated, soft, epithelialized mass was noted on the right major labium. The patient elected to undergo surgical removal of the lesion. Under local-regional anesthesia, the peduncle was clamped and excised using bipolar energy. The final histopathological evaluation identified a fibroepithelial polyp characterized by a hyperplastic squamous epithelium with acanthosis. The postoperative course was uneventful, and no recurrence has been identified after 18 months. Conclusion:: Fibroepithelial polyps are rare benign tumors characterized by a possible grow to over 20 cm. It is important to make a differential diagnosis from malignant lesions and perform a complete excision surgery to reduce the possibility of recurrence.
Calagna et al. (2026) studied this question.