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May 17, 2026Pharmacology Research & PerspectivesOpen Access

Activation of TREK ‐1 and TREK ‐2 Two‐Pore Domain Potassium Channels by the K v 4 Channel Modulator, NS5806

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Authors

EVE. L. VealePMP. M. MatthewsARA. M. Rush

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Overview

Randomized trial shows NS5806 activates TREK channels in neurons, suggesting broader potassium channel interactions.

Key Points

  • The study aims to investigate the effect of NS5806 on TREK-1 and TREK-2 potassium channels in trigeminal neurons.
  • Examined the effects of NS5806 on resting membrane potential in trigeminal neurons.
  • Assessed activation of TREK-1 and TREK-2 channels in sensory neurons.
  • NS5806 caused significant hyperpolarization of the resting membrane potential in trigeminal neurons.
  • Both TREK-1 and TREK-2 channels were activated by NS5806, indicating broader potassium channel activity.

Cite This Study

Veale et al. (2026) studied this question.

synapsesocial.com/papers/6a095b5d7880e6d24efe10c0https://doi.org/10.1002/prp2.70264
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