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May 17, 2026Journal of Paediatrics and Child Health

What Is the Significance of an Accelerated BCG Reaction in Children Living in Low Tuberculosis Incidence Countries?

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Authors

WSWidad Al SalmiNJNiall JohnstonEBEmma Birrell

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Overview

Retrospective case series describes accelerated BCG reactions in children, indicating self-limiting responses in low-incidence settings.

Key Points

  • The aim is to assess the significance of accelerated BCG reactions in children vaccinated in low tuberculosis incidence countries.
  • Retrospective case series conducted at a quaternary hospital in Sydney, NSW.
  • Included 304 children receiving intradermal Danish strain 1331 BCG from December 2023 to December 2024.
  • Collected data on demographics, TB exposure risks, and clinical outcomes regarding accelerated reactions.
  • Among 304 vaccinated children, 14 (5%) developed accelerated reactions.
  • Most reactions (12/14) occurred within 24–48 hours, with no cases of M. tuberculosis infection diagnosed.
  • All reactions were self-limiting, resolving without the need for antimycobacterial therapy.

Cite This Study

Salmi et al. (2026) studied this question.

synapsesocial.com/papers/6a095b787880e6d24efe135fhttps://doi.org/10.1111/jpc.70423
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