In this study, a hierarchical design strategy is introduced for tuning the release of rosmarinic acid (RA) from electrospun poly(L-lactide) (PLA) fibrous materials via surface engineering with chitosan/hyaluronic acid (Ch/HA) polyelectrolyte complexes (PECs). RA was selectively incorporated within the fiber bulk, the PEC coating, or both, enabling control over its spatial distribution. The PEC coating, formed by sequential dip coating, was shown to act as a diffusion-regulating layer with a dual role—either retarding RA release or promoting rapid initial release when functioning as a surface-associated reservoir. As a result, the release kinetics could be systematically tuned depending on the coating architecture and RA localization. Thorough characterization confirmed successful coating formation, enhanced surface hydrophilicity, and improved mechanical performance. All RA-loaded materials retained high antioxidant activity and exhibited pronounced antibacterial and antifungal effects against Staphylococcus aureus, Escherichia coli, and Candida albicans. This work introduces PEC-modified electrospun systems as a versatile platform for the rational design of multifunctional fibrous biomaterials with controlled release profiles, with potential applications in wound healing and drug delivery.
Kyuchyuk et al. (2026) studied this question.