This research investigates the effect of fucoxanthin on experimental autoimmune encephalomyelitis (EAE) and its mechanism of action.
Fucoxanthin was administered to EAE models to assess its effects on microglial activation.
Evaluation of M1 polarization and the activity of the NLRP3 inflammasome was performed.
Assessments included measuring inflammation and neural symptoms associated with EAE.
Fucoxanthin significantly reduced microglial M1 polarization, leading to decreased inflammation.
Inhibition of NLRP3-mediated pyroptosis was observed, contributing to improved neural outcomes.
Overall, fucoxanthin demonstrated therapeutic potential for multiple sclerosis through modulation of immune pathways.
Abstract
Fucoxanthin, an algal compound, attenuates EAE by inhibiting microglial M1 polarization and NLRP3-mediated pyroptosis, suggesting its potential as a therapy for multiple sclerosis.