The SEX-SHOCK score integrates clinical, biological, and functional variables to provide superior and consistent prediction of in-hospital cardiogenic shock across sexes in patients with acute coronary syndrome.
Does the SEX-SHOCK score improve the prediction of in-hospital cardiogenic shock in ACS patients undergoing PCI compared to the ORBI risk score?
The SEX-SHOCK score offers an improved, sex-consistent tool for early risk stratification of cardiogenic shock in ACS patients.
Cardiogenic shock remains the leading cause of in-hospital mortality after acute coronary syndromes, with persistently high fatality rates underscoring the need for accurate early risk stratification. The ORBI risk score was the first tool specifically designed to predict in-hospital cardiogenic shock in ACS patients undergoing PCI, but its discriminative performance is modest and sex-dependent, with lower accuracy in females. Leveraging large multinational cohorts and contemporary modeling techniques, the SEX-SHOCK score integrates key clinical, biological, and functional variables to address these limitations. Its superior and consistent performance across sexes and validation cohorts supports its preferential use for individualized risk prediction, trial design, and modern ACS management.
Simon Kraler (Fri,) conducted a review in Acute coronary syndrome (ACS) (n=53,537). SEX-SHOCK Score vs. ORBI risk score was evaluated on In-hospital cardiogenic shock. The SEX-SHOCK score integrates clinical, biological, and functional variables to provide superior and consistent prediction of in-hospital cardiogenic shock across sexes in patients with acute coronary syndrome.