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May 17, 2026Nature ChemistryOpen Access

A synthetic cell microreactor with two types of interacting dynamic DNA-based pores

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Authors

SFSisi FanLDLongjiang DingBRBenjamin Renz

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Overview

Randomized trial demonstrates biochemical reactions in a synthetic cell microreactor, indicating its potential to replicate cellular complexity.

Key Points

  • This research aims to reconstruct cellular complexity using a synthetic microreactor with dynamic DNA-based pores.
  • Developed a double-necked synthetic cell microreactor (DCM) using giant unilamellar vesicles.
  • Created and tested two types of dynamic DNA-based pores for molecular delivery.
  • Conducted biochemical reactions like glucose oxidase–myoglobin cascade and cell-free RNA transcription.
  • Demonstrated high precision in on-demand delivery of molecular reactants.
  • Successfully conducted confined biochemical reactions, including actin polymerization and DNA crystal synthesis.
  • Showed that the DCM can expand the functional complexity of natural cellular systems.

Cite This Study

Fan et al. (2026) studied this question.

synapsesocial.com/papers/6a095bdd7880e6d24efe1af6https://doi.org/10.1038/s41557-026-02124-7
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