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May 17, 2026Macromolecular BioscienceOpen Access

Recent Advances in Natural Polymers‐based Hydrogels for Periodontal Regeneration

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Authors

JNJoão de Freitas Gomes NetoTLTainara de Paula de Lima LimaLBLuiza Meurer Brand

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Overview

Review summarizes advances in natural polymer-based hydrogels for periodontal regeneration, highlighting implications for tissue engineering.

Key Points

  • The aim is to summarize the recent developments in hydrogels made from natural polymers for periodontal tissue engineering.
  • Review of hydrogels composed of alginate, collagen, and chitosan for periodontal applications.
  • Discussion of crosslinking strategies and processing approaches like 3D bioprinting.
  • Examination of hybrid systems and their effects on cell adhesion and tissue regeneration.
  • Robust preclinical evidence supports coordinated regeneration of cementum and periodontal tissues.
  • Challenges include lack of well-controlled clinical trials and regulatory issues for translation.
  • Emphasis on immunomodulatory and stimuli-responsive designs tailored for the periodontal environment.

Cite This Study

Neto et al. (2026) studied this question.

synapsesocial.com/papers/6a095c2c7880e6d24efe2281https://doi.org/10.1002/mabi.70194
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Also Consider

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  1. 1Next-Generation Natural Hydrogels in Oral Tissue Engineering2025 · 16 citations
  2. 2Hydrogel-Based Therapeutic Strategies for Periodontal Tissue Regeneration: Advances, Challenges, and Future Perspectives2025 · 5 citations
  3. 3Advances in the application of novel smart hydrogels for periodontal tissue regeneration2026
  4. 4Hydrogel-Based Therapies for Periodontal Wound Healing2026
  5. 5Hydrogels in Periodontal and Craniofacial Regeneration: Current Applications and Next‐Generation Biomaterials2026 · 1 citations