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May 17, 2026Gastroenterology reportOpen Access

Effect of modified Zengye decoction on age-related constipation via modulation of the host–microbial metabolic axis

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Authors

DLDeliang LiuYCYuying ChenJPJinzhi Pan

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Overview

Randomized trial investigates modified Zengye decoction effects on constipation in aged rats, indicating promising benefits for gut health.

Key Points

  • This research aims to assess the therapeutic effects of modified Zengye decoction on age-related constipation and its impact on the gut microbiome.
  • Aged constipated rats were gavage-fed with or without modified Zengye decoction.
  • Fecal samples underwent 16S rRNA gene sequencing and 1H nuclear magnetic resonance spectroscopy for analysis.
  • Evaluation of indicators related to constipation was performed post-treatment.
  • Modified Zengye decoction significantly improved intestinal peristalsis and antioxidant capacity.
  • The abundance of beneficial bacteria (Corynebacterium, Roseburia, Clostridium) increased 6-fold, 4-fold, and 3-fold, respectively.
  • Increased expression of Mucin 2 protein, enhanced moisture content in the small intestine, and a reduction in pro-inflammatory cytokines were observed.

Cite This Study

Liu et al. (2026) studied this question.

synapsesocial.com/papers/6a095c3f7880e6d24efe25b8https://doi.org/10.1093/gastro/goag031
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