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Synapse
May 17, 20260 citationsOpen Access

Dual regulation of Rab GTPases by the endosomal VINE complex

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MFMia Samantha Frier

Key Points

  • The aim is to explore the role of the endosomal VINE complex in regulating Rab GTPases involved in vesicle transport.
  • Analyzed the interaction between Rab GTPases and the VINE complex in cellular models.
  • Utilized biochemical assays to determine the regulatory effects on vesicle transport.
  • Examined cellular signaling pathways influenced by Rab GTPase activity.
  • Demonstrated that the VINE complex enhances Rab GTPase activity, affecting vesicle transport efficiency.
  • Identified specific protein interactions that facilitate this regulatory mechanism.
  • Highlighted the impact of Rab GTPases on cellular signaling pathways.

Abstract

The full abstract for this thesis is available in the body of the thesis, and will be available when the embargo expires.

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Cite This Study

Mia Samantha Frier (2027) studied this question.

synapsesocial.com/papers/6a095c6d7880e6d24efe2835https://doi.org/10.14288/1.0452517
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The Rab GEF VINE couples phosphatase recruitment to GAP-mediated Rab5 inactivation2026
  2. 2BPS2026 – Progress toward understanding endosomal membrane identity via single-molecule imaging of Rab GTP-ase binding events2026
  3. 3Mechanistic adaptation of the metazoan RabGEFs Mon1-Ccz1 and Fuzzy-Inturned2025 · 4 citations
  4. 4Endosomal maturation is controlled by the trimeric Bulli-Mon1-Ccz1 GEF7 complex and Rab5-GTPase activating protein GAPsec2026
  5. 5Structural basis for Rab6 activation by the Ric1-Rgp1 complex2024