Management using the Cordella PA sensor system in patients with NYHA class III heart failure resulted in 0.89 HF events or deaths per patient over 24 months (95% CI 0.81-0.99).
Does remote heart failure management using the Cordella PA pressure sensor system reduce heart failure events and mortality in patients with NYHA class III symptoms?
Patients with New York Heart Association (NYHA) class III symptoms, regardless of ejection fraction (EF).
Patient management using the Cordella PA pressure sensor system (comprehensive remote monitoring of vital signs, seated mean pulmonary artery pressure, and patient-reported symptoms via a digital platform).
Incidence of heart failure events or all-cause mortality (HFE/D) at 24 months.composite
Remote monitoring using the Cordella PA sensor system supports sustained low event rates at 2 years in patients with NYHA class III heart failure, regardless of ejection fraction.
BACKGROUND: In the PROACTIVE-HF trial, remote heart failure (HF) management using comprehensive vital signs and seated mean pulmonary artery pressure (mPAP) was safe and resulted in a low reported rate of HF hospitalization (HFH) and all-cause mortality (HFH/D) through 12 months. In this report, we extend the results from the PROACTIVE-HF study through 2 years, stratified by ejection fraction (EF). METHODS AND RESULTS: PROACTIVE-HF was a prospective, multicenter, open-label, single-arm trial evaluating the safety and efficacy of patient management using the Cordella PA pressure sensor system in patients with New York Heart Association class III symptoms, regardless of EF. In the first 24 months, the incidence of HF events (HFE)/D was 0.89 (95% CI 0.81-0.99) events per patient, driven by HFH. Patients with HF with reduced EF had greater HFE/D rates than those with HF with preserved EF (1.0 vs 0.8 events per patient, P = .048). CONCLUSIONS: For patients with HF experiencing moderate-to-severe symptoms, management using the Cordella PA sensor system was associated with low event rates and improved health status at 2 years, regardless of EF. Comprehensive remote monitoring of vital signs, seated PAP, and patient-reported symptoms via a digital platform supports sustained benefit for high-risk patients with HF.
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Guichard et al. (Sun,) conducted a other in Heart failure. Cordella PA pressure sensor system was evaluated on Incidence of HF events or death (HFE/D) (95% CI 0.81-0.99). Management using the Cordella PA sensor system in patients with NYHA class III heart failure resulted in 0.89 HF events or deaths per patient over 24 months (95% CI 0.81-0.99).
www.synapsesocial.com/papers/6a09e43916dfdfe7ed3471a4 — DOI: https://doi.org/10.1016/j.cardfail.2026.01.023
Jason L. Guichard
Eric L. Bonno
Michael E. Nassif
Journal of Cardiac Failure
University of California, San Francisco
Oregon Health & Science University
Vanderbilt University Medical Center
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