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Synapse
May 18, 2026Immunity1 citationsOpen Access

Aged circulating CD8+ T cells and their secreted factors drive cognitive decline

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JSJuliana SucharovGBGregor BieriKPKarishma J.B. Pratt

Key Points

  • The study aims to investigate the role of aged circulating CD8+ T cells and their secreted factors in cognitive decline.
  • Evaluated the impact of T cell-derived factors on cognitive function in aged subjects.
  • Measured specific secreted factors associated with CD8+ T cells.
  • Analyzed cognitive performance metrics in relation to T cell activity.
  • Cognitive performance declines significantly with increased aged CD8+ T cell activity.
  • Specific secreted factors correlate with measurable cognitive decline, suggesting a direct impact.
  • Identified potential therapeutic targets from these T cell-derived factors for cognitive rescue.

Abstract

T cell-derived circulating factors as potential therapeutic targets to rescue cognition in old age.

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Cite This Study

Sucharov et al. (2026) studied this question.

synapsesocial.com/papers/6a0aabc25ba8ef6d83b6f669https://doi.org/10.1016/j.immuni.2026.04.014
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