What does this research mean for the field?

Bioavailable metabolites produced after oral ingestion of a keratin-derived hydrolysate promote human dermal fibroblast hydration and migration while protecting against oxidative stress-induced senescence and apoptosis. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

This study examines the impact of bioavailable metabolites from keratin hydrolysate on human dermal fibroblast functions and oxidative stress protection.

May 18, 2026Frontiers in NutritionOpen Access

Bioavailable human metabolites of a keratin-derived hydrolysate promote primary human dermal fibroblast activities and protect against oxidative stress-related damages

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Authors

FWFabien Wauquier LBLine Boutin-Wittrant JSJean‐Philippe Soulard

Discussion

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Overview

Randomized trial demonstrates fibroblast activity enhancement in men after ingesting keratin hydrolysate, suggesting benefits for skin health.

Key Points

This study examines the impact of bioavailable metabolites from keratin hydrolysate on human dermal fibroblast functions and oxidative stress protection.
Ten healthy men ingested 5,000 mg of keratin hydrolysate (Kera-Diet®).
Plasma amino acids were measured using UPLC–MS over 240 minutes to identify absorption peaks.
Fibroblasts were exposed to naïve or enriched serum to assess cellular viability, migration, and oxidative stress responses.
Circulating amino acids peaked approximately 20 minutes after ingestion.
Enriched serum increased glycosaminoglycan release by 11% and hyaluronan by 43%, enhancing fibroblast migration.
Under oxidative stress, Kera-Diet® significantly reduced ROS and apoptosis while maintaining fibroblast viability.

Cite This Study

Wauquier et al. (2026) studied this question.

synapsesocial.com/papers/6a0aabc25ba8ef6d83b6f7b0 https://doi.org/10.3389/fnut.2026.1812320

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May 18, 2026Frontiers in NutritionOpen Access

Bioavailable human metabolites of a keratin-derived hydrolysate promote primary human dermal fibroblast activities and protect against oxidative stress-related damages

View Full Paper

Ask AI

Bookmark

Authors

FWFabien Wauquier LBLine Boutin-Wittrant JSJean‐Philippe Soulard

Discussion

Member takes

Overview

Randomized trial demonstrates fibroblast activity enhancement in men after ingesting keratin hydrolysate, suggesting benefits for skin health.

Key Points

This study examines the impact of bioavailable metabolites from keratin hydrolysate on human dermal fibroblast functions and oxidative stress protection.
Ten healthy men ingested 5,000 mg of keratin hydrolysate (Kera-Diet®).
Plasma amino acids were measured using UPLC–MS over 240 minutes to identify absorption peaks.
Fibroblasts were exposed to naïve or enriched serum to assess cellular viability, migration, and oxidative stress responses.
Circulating amino acids peaked approximately 20 minutes after ingestion.
Enriched serum increased glycosaminoglycan release by 11% and hyaluronan by 43%, enhancing fibroblast migration.
Under oxidative stress, Kera-Diet® significantly reduced ROS and apoptosis while maintaining fibroblast viability.

Cite This Study

Wauquier et al. (2026) studied this question.

synapsesocial.com/papers/6a0aabc25ba8ef6d83b6f7b0 https://doi.org/10.3389/fnut.2026.1812320

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