Estimated glucose disposal rate outperforms conventional insulin resistance indices in predicting acute kidney injury risk among individuals with diabetes and prediabetes
Prospective cohort study finds eGDR better predicts AKI risk in individuals with dysglycemia, suggesting clinical utility.
Key Points
The study aims to evaluate the relationship between estimated glucose disposal rate (eGDR) and acute kidney injury (AKI) risk among individuals with diabetes and prediabetes.
Analyzed 60,149 UK Biobank participants with diabetes or prediabetes
Calculated eGDR using waist circumference, hypertension status, and HbA1c
Used multivariable Cox models to assess eGDR-AKI risk relationship
6,259 participants developed AKI over a median follow-up of 13.4 years
Higher eGDR associated with a 62% lower AKI risk (adjusted HR: 0.38; 95%CI: 0.34-0.43)
eGDR showed superior discriminative ability with C-index 0.709 compared to other IR indices.